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Article

Regulation of Immune Responses by the Neonatal Fc Receptor and Its Therapeutic Implications

5 Jan 2015

Abstract excerpt

As a single receptor, the neonatal Fc receptor (FcRn) is critically involved in regulating albumin and IgG serum concentrations by protecting these two ligands from degradation. In addition to these essential homeostatic functions, FcRn possesses important functions in regulating immune responses that are equally as critical and are increasingly coming to attention. During the first stages of life, FcRn mediates...

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PMID: 25601863
DOI: 10.3389/fimmu.2014.00664

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