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Article

FcRn, but not FcγRs, drives maternal-fetal transplacental transport of human IgG antibodies

27 May 2020

Abstract excerpt

The IgG Fc domain has the capacity to interact with diverse types of receptors, including the neonatal Fc receptor (FcRn) and Fcγ receptors (FcγRs), which confer pleiotropic biological activities. Whereas FcRn regulates IgG epithelial transport and recycling, Fc effector activities, such as antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis, are mediated by FcγRs, which upon cross-linking transduce...

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PMID: 32461366
DOI: 10.1073/pnas.2004325117

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