Article

FcRn, but not FcγRs, drives maternal-fetal transplacental transport of human IgG antibodies

2020-03-25

Abstract excerpt

The IgG Fc domain has the capacity to interact with diverse types of receptors, including FcRn and FcγRs, which confer pleiotropic biological activities. Whereas FcRn regulates IgG epithelial transport and recycling, Fc effector activities, such as ADCC and phagocytosis are mediated by FcγRs, which upon crosslinking transduce signals that modulate the function of effector leukocytes. Despite the well-defined and n...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 72620896-b479-5a66-b2d2-3cc6ddf14594
DOI: 10.1101/2020.03.22.999243

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

FcRn, but not FcγRs, drives maternal-fetal transplacental transport of human IgG antibodiesDOI 10.1101/2020.03.22.999243Read

FcRn, but not FcγRs, drives maternal-fetal transplacental transport of human IgG antibodiesSemantic proximity Read

Multiple Roles for the Major Histocompatibility Complex Class I– Related Receptor FcRnSemantic proximity Read

Maternofetal transplacental transport of recombinant IgG antibodies lacking effector functionsSemantic proximity Read

Regulation of Immune Responses by the Neonatal Fc Receptor and Its Therapeutic ImplicationsSemantic proximity Read

The immunologic functions of the neonatal Fc receptor for IgG.Semantic proximity Read

Contribution of Human FcÎ³Rs to Disease with Evidence from Human Polymorphisms and Transgenic Animal StudiesSemantic proximity Read

IgG Subclasses and Allotypes: From Structure to Effector FunctionsSemantic proximity Read

Neonatal Fc receptor (FcRn): a novel target for therapeutic antibodies and antibody engineering.Semantic proximity Read

The MHC class I-related receptor, FcRn, plays an essential role in the maternofetal transfer of gamma-globulin in humans.Semantic proximity Read

The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinitySemantic proximity Read

Update on Transplacental Transfer of IgG Subclasses: Impact of Maternal and Fetal FactorsSemantic proximity Read

Identification and function of neonatal Fc receptor in mammary gland of lactating miceSemantic proximity Read