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Article

Identification of critical IgG binding epitopes on the neonatal Fc receptor.

Journal of molecular biology - 12 Dec 1997

Vaughn D E, Milburn C M, Penny D M, Martin W L, Johnson J L, Bjorkman P J

Abstract excerpt

The neonatal Fc receptor (FcRn) binds maternal immunoglobulin G (IgG) during the acquisition of passive immunity by the fetus or newborn. FcRn also binds IgG and returns it to the bloodstream, thus protecting IgG from a default degradative pathway. Biosensor assays have been used to characterize the interaction of a soluble form of rat FcRn with IgG, and demonstrate that FcRn dimerization and immobilization are...

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Identifiers

PMID: 9417938
DOI: 10.1006/jmbi.1997.1388

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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