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Article

Divergent activities of an engineered antibody in murine and human systems have implications for therapeutic antibodies.

Proceedings of the National Academy of Sciences of the United States of America - 5 Dec 2006

Vaccaro Carlos, Bawdon Roger, Wanjie Sylvia, Ober Raimund J, Ward E Sally

Abstract excerpt

The MHC class I-related receptor, neonatal Fc receptor (FcRn), plays a central role in regulating the transport and in vivo persistence of immunoglobulin G (IgG). IgG-FcRn interactions can be targeted for engineering to modulate the in vivo longevity and transport of an antibody, and this has implications for the successful application of therapeutic IgGs. Although mice are widely used to preclinically test...

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Share to Amino Acid Substitution
Share to Binding Sites, Antibody

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histocompatibility Antigens Class I

Share to Immunoglobulin G

Share to Mutagenesis, Site-Directed

Share to Protein Engineering

Share to Receptors, Fc

Source

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Identifiers

PMID: 17116867
DOI: 10.1073/pnas.0606304103
PMCID: PMC1693727

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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