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Article

Nkx2.7 and Nkx2.5 function redundantly and are required for cardiac morphogenesis of zebrafish embryos.

PloS one - 1 Jan 2009

Tu Chi-Tang, Yang Tzu-Ching, Tsai Huai-Jen

Abstract excerpt

BACKGROUND: Nkx2.7 is the tinman-related gene, as well as orthologs of Nkx2.5 and Nkx-2.3. Nkx2.7 and Nkx2.5 express in zebrafish heart fields of lateral plate mesoderm. The temporal and spatial expression patterns of Nkx2.7 are similar to those of Nkx2.5, but their functions during cardiogenesis remain unclear. METHODOLOGY/PRINCIPAL FINDINGS: Here, Nkx2.7 is demonstrated to compensate for Nkx2.5 loss of function...

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Identifiers

PMID: 19158954
DOI: 10.1371/journal.pone.0004249
PMCID: PMC2626283

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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