Article
Neural deletion of Sh2b1 results in brain growth retardation and reactive aggression.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2018
Jiang Lin, Su Haoran, Keogh Julia M, Chen Zheng, Henning Elana, Wilkinson Paul, Goodyer Ian, Farooqi I Sadaf, Rui Liangyou
Abstract excerpt
Psychiatric disorders are associated with aberrant brain development and/or aggressive behavior and are influenced by genetic factors; however, genes that affect brain aggression circuits remain elusive. Here, we show that neuronal Src-homology-2 (SH2)B adaptor protein-1 ( Sh2b1) is indispensable for both brain growth and protection against aggression. Global and brain-specific deletion of Sh2b1 decreased brain...
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