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Article

A deletion in tropomyosin-related kinase B and the development of human anxiety.

Biological psychiatry - 15 Mar 2011

Ernst Carl, Wanner Brigitte, Brezo Jelena, Vitaro Frank, Tremblay Richard, Turecki Gustavo

Abstract excerpt

BACKGROUND: The tropomyosin-related kinase B (TrkB)/brain-derived neurotrophic factor system has been associated with psychiatric disorders, and animal models of defects in this system suggest that it might have a particular role in anxiety. METHODS: DNA sequencing and cloning were used to identify a mutation in TrkB, and four different cell lines were used to assess functionality. Clinical samples were from a...

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Identifiers

PMID: 21126736
DOI: 10.1016/j.biopsych.2010.10.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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