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Article

Hydroxyurea sensitivity reveals a role for ISC1 in the regulation of G2/M.

The Journal of biological chemistry - 27 Mar 2009

Matmati Nabil, Kitagaki Hiroshi, Montefusco David, Mohanty Bidyut K, Hannun Yusuf A

Abstract excerpt

Saccharomyces cerevisiae cells lacking ISC1 (inositol phosphosphingolipase C) exhibit sensitivity to genotoxic agents such as methyl methanesulfonate and hydroxyurea (HU). Cell cycle analysis by flow cytometry revealed a G(2)/M block in isc1Delta cells when treated with methyl methanesulfonate or HU. Further investigation revealed that the levels of Cdc28 phosphorylated on Tyr-19, which plays an essential role in...

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Share to CDC28 Protein Kinase, S cerevisiae
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19158081
DOI: 10.1074/jbc.M900004200
PMCID: PMC2659181

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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