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Article

Isc1p plays a key role in hydrogen peroxide resistance and chronological lifespan through modulation of iron levels and apoptosis.

Molecular biology of the cell - 1 Mar 2008

Almeida Teresa, Marques Marta, Mojzita Dominik, Amorim Maria A, Silva Rui D, Almeida Bruno, Rodrigues Pedro, Ludovico Paula, Hohmann Stefan, Moradas-Ferreira Pedro, Côrte-Real Manuela, Costa Vítor

Abstract excerpt

The inositolphosphosphingolipid phospholipase C (Isc1p) of Saccharomyces cerevisiae belongs to the family of neutral sphingomyelinases that generates the bioactive sphingolipid ceramide. In this work the role of Isc1p in oxidative stress resistance and chronological lifespan was investigated. Loss of Isc1p resulted in a higher sensitivity to hydrogen peroxide that was associated with an increase in oxidative...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18162582
DOI: 10.1091/mbc.e07-06-0604
PMCID: PMC2262964

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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