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Article

A role for Saccharomyces cerevisiae Chk1p in the response to replication blocks.

Molecular biology of the cell - 1 Sept 2004

Schollaert Kaila L, Poisson Julie M, Searle Jennifer S, Schwanekamp Jennifer A, Tomlinson Craig R, Sanchez Yolanda

Abstract excerpt

Replication blocks and DNA damage incurred during S phase activate the S-phase and intra-S-phase checkpoint responses, respectively, regulated by the Atrp and Chk1p checkpoint kinases in metazoans. In Saccharomyces cerevisiae, these checkpoints are regulated by the Atrp homologue Mec1p and the kinase Rad53p. A conserved role of these checkpoints is to block mitotic progression until DNA replication and repair are...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 15229282
DOI: 10.1091/mbc.e03-11-0792
PMCID: PMC515340

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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