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Article

Regulation of Sphingolipid Biosynthesis by the Morphogenesis Checkpoint Kinase Swe1.

The Journal of biological chemistry - 29 Jan 2016

Chauhan Neha, Han Gongshe, Somashekarappa Niranjanakumari, Gable Kenneth, Dunn Teresa, Kohlwein Sepp D

Abstract excerpt

Sphingolipid (SL) biosynthesis is negatively regulated by the highly conserved endoplasmic reticulum-localized Orm family proteins. Defective SL synthesis in Saccharomyces cerevisiae leads to increased phosphorylation and inhibition of Orm proteins by the kinase Ypk1. Here we present evidence that the yeast morphogenesis checkpoint kinase, Swe1, regulates SL biosynthesis independent of the Ypk1 pathway. Deletion...

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Identifiers

PMID: 26634277
DOI: 10.1074/jbc.M115.693200
PMCID: PMC4732232

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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