Article
Mechanisms of field cancerization in the human stomach: the expansion and spread of mutated gastric stem cells.
Gastroenterology - 1 Feb 2008
McDonald Stuart A C, Greaves Laura C, Gutierrez-Gonzalez Lydia, Rodriguez-Justo Manuel, Deheragoda Maesha, Leedham Simon J, Taylor Robert W, Lee Chung Yin, Preston Sean L, Lovell Matthew, Hunt Toby, Elia George, Oukrif Dahmane, Harrison Rebecca, Novelli Marco R, Mitchell Ian, Stoker David L, Turnbull Douglass M, Jankowski Janusz A Z, Wright Nicholas A
Abstract excerpt
BACKGROUND & AIMS: How mutations are established and spread through the human stomach is unclear because the clonal structure of gastric mucosal units is unknown. Here we investigate, using mitochondrial DNA (mtDNA) mutations as a marker of clonal expansion, the clonality of the gastric unit and show how mutations expand in normal mucosa and gastric mucosa showing intestinal metaplasia. This has important...
Topics
- Cell Transformation, Neoplastic
- DNA, Mitochondrial
- Electron Transport Complex IV
- Epithelium
- Gastric Mucosa
- Genotype
- Humans
- Metaplasia
- Multipotent Stem Cells