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Article

A methodological approach to tracing cell lineage in human epithelial tissues.

Stem cells (Dayton, Ohio) - 1 Jun 2009

Fellous Tariq G, McDonald Stuart A C, Burkert Julia, Humphries Adam, Islam Shahriar, De-Alwis Nemantha M W, Gutierrez-Gonzalez Lydia, Tadrous Paul J, Elia George, Kocher Hemant M, Bhattacharya Satyajit, Mears Lisa, El-Bahrawy Mona, Turnbull Douglas M, Taylor Robert W, Greaves Laura C, Chinnery Patrick F, Day Christopher P, Wright Nicholas A, Alison Malcolm R

Abstract excerpt

Methods for lineage tracing of stem cell progeny in human tissues are currently not available. We describe a technique for detecting the expansion of a single cell's progeny that contain clonal mitochondrial DNA (mtDNA) mutations affecting the expression of mtDNA-encoded cytochrome c oxidase (COX). Because such mutations take up to 40 years to become phenotypically apparent, we believe these clonal patches...

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PMID: 19489031
DOI: 10.1002/stem.67

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