Article
The clonal origins of dysplasia from intestinal metaplasia in the human stomach.
Gastroenterology - 1 Apr 2011
Gutierrez-Gonzalez Lydia, Graham Trevor A, Rodriguez-Justo Manuel, Leedham Simon J, Novelli Marco R, Gay Laura J, Ventayol-Garcia Tania, Green Alicia, Mitchell Ian, Stoker David L, Preston Sean L, Bamba Shigeki, Yamada Eiji, Kishi Yuuki, Harrison Rebecca, Jankowski Janusz A, Wright Nicholas A, McDonald Stuart A C
Abstract excerpt
BACKGROUND & AIMS: Studies of the clonal architecture of gastric glands with intestinal metaplasia are important in our understanding of the progression from metaplasia to dysplasia. It is not clear if dysplasias are derived from intestinal metaplasia or how dysplasias expand. We investigated whether cells within a metaplastic gland share a common origin, whether glands clonally expand by fission, and determine...
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