Article
A comparative study of HLA binding affinity and ligand diversity: implications for generating immunodominant CD8+ T cell responses.
Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2009
Rao Xiangyu, Costa Ana Isabel C A Fontaine, van Baarle Debbie, Kesmir Can
Abstract excerpt
Conventional CD8(+) T cell responses against intracellular infectious agents are initiated upon recognition of pathogen-derived peptides presented at the cell surface of infected cells in the context of MHC class I molecules. Among the major MHC class I loci, HLA-B is the swiftest evolving and the most polymorphic locus. Additionally, responses restricted by HLA-B molecules tend to be dominant, and most...
Topics
- Alleles
- Amino Acid Motifs
- Antigen Presentation
- CD8-Positive T-Lymphocytes
- Cytotoxicity, Immunologic
- Genome, Bacterial
- Genome, Viral
- HLA-A Antigens
- HLA-B Antigens
- Humans
- Immunodominant Epitopes
- Ligands
- Peptides
- Protein Binding
- Proteome