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Article

A comparative study of HLA binding affinity and ligand diversity: implications for generating immunodominant CD8+ T cell responses.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2009

Rao Xiangyu, Costa Ana Isabel C A Fontaine, van Baarle Debbie, Kesmir Can

Abstract excerpt

Conventional CD8(+) T cell responses against intracellular infectious agents are initiated upon recognition of pathogen-derived peptides presented at the cell surface of infected cells in the context of MHC class I molecules. Among the major MHC class I loci, HLA-B is the swiftest evolving and the most polymorphic locus. Additionally, responses restricted by HLA-B molecules tend to be dominant, and most...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19155500
DOI: 10.4049/jimmunol.182.3.1526

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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