Article

Predicted epitope binding core motifs and common amino acid polymorphisms distinguish protective- from susceptibility-associated HLA alleles in leishmaniasis

2021-02-20

Abstract excerpt

Susceptibility for leishmaniasis is largely dependent on genetic- and immune factors of the host. Despite the previously described association of human leukocyte antigen (HLA) gene cluster variants as genetic susceptibility factors, little is known on the mechanisms that mediate these associations. To characterize the functionality underpinning these associations between HLA and disease, we predicted the epitope b...

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Literature Corpus work: 51cc1a86-0e53-5fa3-99e7-01c2ff24555c
DOI: 10.1101/2021.02.19.431981

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