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Article

Uncovering the peptide-binding specificities of HLA-C: a general strategy to determine the specificity of any MHC class I molecule.

Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 2014

Rasmussen Michael, Harndahl Mikkel, Stryhn Anette, Boucherma Rachid, Nielsen Lise Lotte, Lemonnier François A, Nielsen Morten, Buus Søren

Abstract excerpt

MHC class I molecules (HLA-I in humans) present peptides derived from endogenous proteins to CTLs. Whereas the peptide-binding specificities of HLA-A and -B molecules have been studied extensively, little is known about HLA-C specificities. Combining a positional scanning combinatorial peptide library approach with a peptide-HLA-I dissociation assay, in this study we present a general strategy to determine the...

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Identifiers

PMID: 25311805
DOI: 10.4049/jimmunol.1401689
PMCID: PMC4226424

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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