NKG2D Signaling Leads to NK Cell Mediated Lysis of Childhood AML.

Abstract excerpt

Natural killer cells have been shown to be relevant in the recognition and lysis of acute myeloid leukemia. In childhood acute lymphoblastic leukemia, it was shown that HLA I expression and KIR receptor-ligand mismatch significantly impact ALL cytolysis. We characterized 14 different primary childhood AML blasts by flow cytometry including NKG2D ligands. Further HLA I typing of blasts was performed and HLA I on...

Topics

• Case-Control Studies
• Cell Line, Tumor
• Child
• Cytotoxicity, Immunologic
• Gene Expression
• Histocompatibility Antigens Class I
• Humans
• Immunophenotyping
• K562 Cells
• Killer Cells, Natural
• Leukemia, Myeloid, Acute
• Ligands
• NK Cell Lectin-Like Receptor Subfamily K