Article
Identification of HLA-unrestricted CD8+/CD28- cytotoxic T-cell clones specific for leukemic blasts in children with acute leukemia.
Cancer research - 1 Sept 1995
Montagna D, Aricò M, Montini E, De Benedetti F, Maccario R
Abstract excerpt
We report on the identification of 57 T-cell clones (TCC) cytolytic to autologous leukemic blasts (LB) but not autologous bone marrow remission cells. LB-reactive TCC were obtained from 3 children with acute leukemia at remission; all expressed the same phenotype, CD3/TCR alpha beta/CD8+, but were heterogeneous for the expression of V beta T-cell receptor (TCR) V region chains, thus showing that these cells were...
Topics
- Antibodies, Monoclonal
- Bone Marrow
- CD28 Antigens
- Child
- Humans
- Immunophenotyping
- Leukemia, Myeloid, Acute
- Lymphocyte Subsets
- Phenotype
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- T-Lymphocytes, Cytotoxic