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NK-cell reconstitution after haploidentical hematopoietic stem-cell transplantations: immaturity of NK cells and inhibitory effect of NKG2A override GvL effect.

Blood - 15 May 2005

Nguyen Stephanie, Dhedin Nathalie, Vernant Jean-Paul, Kuentz Mathieu, Al Jijakli Ahmad, Rouas-Freiss Nathalie, Carosella Edgardo D, Boudifa Ali, Debré Patrice, Vieillard Vincent

Abstract excerpt

Natural killer (NK) cell alloreactivity is reported to mediate strong GvL (graft versus leukemia) effect in patients after haploidentical stem-cell transplantation (SCT) for acute myeloid leukemia (AML). Because subsequent immune reconstitution remains a major concern, we studied NK-cell recovery in 10 patients with AML who received haplomismatched SC transplants, among whom no GvL effect was observed, despite...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15687235
DOI: 10.1182/blood-2004-10-4113

Genes

SCT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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