Article
Single-cell analysis of the human NK cell response to missing self and its inhibition by HLA class I.
Blood - 1 Mar 2005
Draghi Monia, Yawata Nobuyo, Gleimer Michael, Yawata Makoto, Valiante Nicholas M, Parham Peter
Abstract excerpt
Natural killer (NK) cells activate quickly in response to pathogens, tumors, and allogeneic hematopoietic cell transplants. Modulating the NK cell response are clonally distributed NK cell receptors that survey cells for change in the expression of major histocompatibility complex (MHC) class I and structurally related ligands. Here the enzyme-linked immunospot (ELISPOT) assay, intracellular cytokine staining...
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