Article
Recognition of adult and pediatric acute lymphoblastic leukemia blasts by natural killer cells.
Haematologica - 1 Jul 2014
Torelli Giovanni F, Peragine Nadia, Raponi Sara, Pagliara Daria, De Propris Maria S, Vitale Antonella, Bertaina Alice, Barberi Walter, Moretta Lorenzo, Basso Giuseppe, Santoni Angela, Guarini Anna, Locatelli Franco, Foà Robin
Abstract excerpt
In this study, we aimed to investigate the pathways of recognition of acute lymphoblastic leukemia blasts by natural killer cells and to verify whether differences in natural killer cell activating receptor ligand expression among groups defined by age of patients, or presence of cytogenetic/molecular aberrations correlate with the susceptibility to recognition and killing. We analyzed 103 newly diagnosed acute...
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