Article
Evidence for a latent precursor (p53 signature) that may precede serous endometrial intraepithelial carcinoma.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Mar 2009
Jarboe Elke A, Pizer Ellen S, Miron Alexander, Monte Nick, Mutter George L, Crum Christopher P
Abstract excerpt
Both serous intraepithelial carcinoma and endometrial glandular dysplasia are associated with uterine serous carcinoma. Recently a candidate serous cancer precursor containing p53 mutations (p53 signature) was described in the fallopian tube. We analyzed normal and neoplastic endometrium for a similar entity. In total 10 endometrial polyps involved by intraepithelial and/or invasive carcinoma and 137 benign...
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