Article
A candidate precursor to serous carcinoma that originates in the distal fallopian tube.
The Journal of pathology - 1 Jan 2007
Lee Y, Miron A, Drapkin R, Nucci M R, Medeiros F, Saleemuddin A, Garber J, Birch C, Mou H, Gordon R W, Cramer D W, McKeon F D, Crum C P
Abstract excerpt
The tubal fimbria is a common site of origin for early (tubal intraepithelial carcinoma or TIC) serous carcinomas in women with familial BRCA1 or 2 mutations (BRCA+). Somatic p53 tumour suppressor gene mutations in these tumours suggest a pathogenesis involving DNA damage, p53 mutation, and progressive loss of cell cycle control. We recently identified foci of strong p53 immunostaining-termed 'p53 signatures'-in...
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