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Article

Candidate serous cancer precursors in fallopian tube epithelium of BRCA1/2 mutation carriers.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Sept 2009

Shaw Patricia A, Rouzbahman Marjan, Pizer Ellen S, Pintilie Melania, Begley Heather

Abstract excerpt

Occult invasive and intraepithelial carcinomas have been identified in the tubal fimbria of BRCA mutation carriers undergoing prophylactic surgery, and recently described lesions overexpressing p53 in the distal tubes of mutation carriers, and non-carriers, have been proposed as histological precursors of high-grade serous carcinoma. The aim of this study was to confirm these findings in a larger, independent...

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Share to Biomarkers, Tumor
Share to Cystadenocarcinoma, Serous

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fallopian Tube Neoplasms

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Share to Immunohistochemistry

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Source

Identifiers

PMID: 19543244
DOI: 10.1038/modpathol.2009.89

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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