Article
A candidate precursor to pelvic serous cancer (p53 signature) and its prevalence in ovaries and fallopian tubes from women with BRCA mutations.
Gynecologic oncology - 1 May 2008
Folkins Ann K, Jarboe Elke A, Saleemuddin Aasia, Lee Yonghee, Callahan Michael J, Drapkin Ronny, Garber Judy E, Muto Michael G, Tworoger Shelley, Crum Christopher P
Abstract excerpt
BACKGROUND: Early serous carcinomas predominate in the fimbria of women with BRCA mutations (BRCA+). An entity in non-neoplastic mucosa sharing several properties of early serous carcinomas--the "p53 signature"--has been described in the distal fallopian tube and proposed as a precursor to serous carcinomas. This study compared the prevalence of p53 signatures in ovarian cortical inclusion cysts (CICs) and...
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