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Article

Differential requirements for clathrin in receptor-mediated endocytosis and maintenance of synaptic vesicle pools.

Proceedings of the National Academy of Sciences of the United States of America - 27 Jan 2009

Sato Ken, Ernstrom Glen G, Watanabe Shigeki, Weimer Robby M, Chen Chih-Hsiung, Sato Miyuki, Siddiqui Ayesha, Jorgensen Erik M, Grant Barth D

Abstract excerpt

Clathrin is a coat protein involved in vesicle budding from several membrane-bound compartments within the cell. Here we present an analysis of a temperature-sensitive (ts) mutant of clathrin heavy chain (CHC) in a multicellular animal. As expected Caenorhabditis elegans chc-1(b1025ts) mutant animals are defective in receptor-mediated endocytosis and arrest development soon after being shifted to the restrictive...

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Identifiers

PMID: 19151157
DOI: 10.1073/pnas.0809541106
PMCID: PMC2633560

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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