Article
Notch down-regulation by endocytosis is essential for pigment cell determination and survival in the Drosophila retina.
Mechanisms of development - 1 Jan 2000
Peralta Susana, Gómez Yolanda, González-Gaitán Marcos A, Moya Fernando, Vinós Javier
Abstract excerpt
The clathrin heavy chain is a fundamental element in endocytosis and therefore, in the internalization of several cell-surface receptors through which cells interact with their environment. Here we show that the only non-lethal mutant allele of the clathrin heavy chain identified to date in metazoans, the Drosophila Chc(4), involves the substitution of a residue at the knee region of the molecule that impairs...
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