Article
UV-induced photolesions, their repair and mutations.
Mutation research - 1 May 1993
Mullenders L H, Hazekamp-van Dokkum A M, Kalle W H, Vrieling H, Zdzienicka M Z, van Zeeland A A
Abstract excerpt
UV-induced cyclobutane pyrimidine dimers (CPD) are selectively removed from the transcribed strand of transcriptionally active genes in V79 Chinese hamster cells. This strand specificity of repair corresponds well with the observation that UV-induced mutations in the HPRT gene are primarily generated by DNA photolesions in the non-transcribed strand. This strand bias for mutations is, however, much more...
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