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Article

UVB-induced cyclobutane pyrimidine dimer frequency correlates with skin cancer mutational hotspots in p53.

Photochemistry and photobiology - 1 Nov 1997

Drouin R, Therrien J P

Abstract excerpt

Ultraviolet light has been identified as the major carcinogen in skin cancer and the p53 tumor suppressor gene is a major target for UV-induced mutations. The mutations are probably caused by unrepaired UV-induced cyclobutane pyrimidine dimers (CPD) and possibly by the less frequent pyrimidine (6...

Topics

Base Sequence
Cells, Cultured
DNA
Genes, p53
Humans
Molecular Sequence Data
Mutation
Neoplasms, Radiation-Induced
Pyrimidine Dimers
Skin Neoplasms
Ultraviolet Rays

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9383997
DOI: 10.1111/j.1751-1097.1997.tb03213.x

Genes

CPD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9383997-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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UVB-induced cyclobutane pyrimidine dimer frequency correlates with skin cancer mutational hotspots in p53.PMID 9383997Read ↗

Sunlight induces pyrimidine dimers preferentially at 5-methylcytosine bases.Semantic proximity Read ↗

Mechanisms of UV-induced mutations and skin cancerSemantic proximity Read ↗

Cyclobutane pyrimidine dimers form preferentially at the major p53 mutational hotspot in UVB-induced mouse skin tumors.Semantic proximity Read ↗

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Deamination of 5-Methylcytosines within Cyclobutane Pyrimidine Dimers Is an Important Component of UVB MutagenesisSemantic proximity Read ↗

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The major mechanism of melanoma mutations is based on deamination of cytosine in pyrimidine dimers as determined by circle damage sequencing.Semantic proximity Read ↗

UVA-induced cyclobutane pyrimidine dimers form predominantly at thymine-thymine dipyrimidines and correlate with the mutation spectrum in rodent cells.Semantic proximity Read ↗

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