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Article

UVB-induced cyclobutane pyrimidine dimer frequency correlates with skin cancer mutational hotspots in p53.

Photochemistry and photobiology - 1 Nov 1997

Drouin R, Therrien J P

Abstract excerpt

Ultraviolet light has been identified as the major carcinogen in skin cancer and the p53 tumor suppressor gene is a major target for UV-induced mutations. The mutations are probably caused by unrepaired UV-induced cyclobutane pyrimidine dimers (CPD) and possibly by the less frequent pyrimidine (6-4) pyrimidone photoproducts. While hot spots for p53 mutations in human nonmelanoma skin tumors correspond quite well...

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Source

Identifiers

PMID: 9383997
DOI: 10.1111/j.1751-1097.1997.tb03213.x

Genes

CPD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

UVB-induced cyclobutane pyrimidine dimer frequency correlates with skin cancer mutational hotspots in p53.PMID 9383997Read ↗

Sunlight induces pyrimidine dimers preferentially at 5-methylcytosine bases.Semantic proximity Read ↗

Mechanisms of UV-induced mutations and skin cancerSemantic proximity Read ↗

Cyclobutane pyrimidine dimers form preferentially at the major p53 mutational hotspot in UVB-induced mouse skin tumors.Semantic proximity Read ↗

Mutations induced by ultraviolet light.Semantic proximity Read ↗

The distribution of UV photoproducts along the human p53 gene and its relation to mutations in skin cancer.Semantic proximity Read ↗

Involvement of 5-methylcytosine in sunlight-induced mutagenesis.Semantic proximity Read ↗

UV wavelength-dependent DNA damage and human non-melanoma and melanoma skin cancer.Semantic proximity Read ↗

Deamination of 5-Methylcytosines within Cyclobutane Pyrimidine Dimers Is an Important Component of UVB MutagenesisSemantic proximity Read ↗

UVA-induced DNA damage and mutations in human melanocytes: relevance for melanoma mutations.Semantic proximity Read ↗

Genome-wide profiles of UV lesion susceptibility, repair, and mutagenic potential in melanoma.Semantic proximity Read ↗

The major mechanism of melanoma mutations is based on deamination of cytosine in pyrimidine dimers as determined by circle damage sequencing.Semantic proximity Read ↗

UVA-induced cyclobutane pyrimidine dimers form predominantly at thymine-thymine dipyrimidines and correlate with the mutation spectrum in rodent cells.Semantic proximity Read ↗

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