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Article

Mapping of UV photoproducts within ras proto-oncogenes in UV-irradiated cells: correlation with mutations in human skin cancer.

Oncogene - 1 Sept 1992

Törmänen V T, Pfeifer G P

Abstract excerpt

Mutations in ras proto-oncogenes have been found in human skin cancers. Since ultraviolet light is implicated in the development of skin cancers, we have investigated the formation of UV-induced photoproducts along exons 1 and 2 of the three ras proto-oncogenes, H-ras, K-ras, and N-ras, in UV-irradiated human cells. The two major types of DNA photoproducts, cyclobutane pyrimidine dimers and pyrimidine (6-4)...

Topics

Base Sequence
Codon
DNA
Female
Genes, ras
Humans
Molecular Sequence Data
Mutation
Photochemistry
Polymerase Chain Reaction
Skin Neoplasms
Ultraviolet Rays

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 1501884

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1501884-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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