Cyclobutane pyrimidine dimers are responsible for the vast majority of mutations induced by UVB irradiation in mammalian cells.

doi:10.1074/jbc.M107696200

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Article

Cyclobutane pyrimidine dimers are responsible for the vast majority of mutations induced by UVB irradiation in mammalian cells.

The Journal of biological chemistry - 30 Nov 2001

You Y H, Lee D H, Yoon J H, Nakajima S, Yasui A, Pfeifer G P

Abstract excerpt

The most prevalent DNA lesions induced by UVB are the cyclobutane pyrimidine dimers (CPDs) and the pyrimidine (6-4) pyrimidone photoproducts ((6-4)PPs). It has been a long standing controversy as to which of these photoproduct is responsible for mutations in mammalian cells. Here we have introduced photoproduct-specific DNA photolyases into a mouse cell line carrying the transgenic mutation reporter genes lacI...

Topics

Animals
Base Sequence
Blotting, Western
Cell Line
Cloning, Molecular
DNA
DNA Damage
DNA Repair
Deoxyribodipyrimidine Photo-Lyase
Dimerization
Dose-Response Relationship, Radiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoblotting

Mice

Mice, Transgenic

Molecular Sequence Data

Mutation

Pyrimidines

Time Factors

Source

Open in PubMed

Identifiers

PMID: 11572873
DOI: 10.1074/jbc.M107696200

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