Article
DNA sequence context greatly affects the accuracy of bypass across an ultraviolet light 6-4 photoproduct in mammalian cells.
Mutation research - 1 Oct 2015
Shriber Pola, Leitner-Dagan Yael, Geacintov Nicholas, Paz-Elizur Tamar, Livneh Zvi
Abstract excerpt
Translesion DNA synthesis (TLS) is a DNA damage tolerance mechanism carried out by low-fidelity DNA polymerases that bypass DNA lesions, which overcomes replication stalling. Despite the miscoding nature of most common DNA lesions, several of them are bypassed in mammalian cells in a relatively accurate manner, which plays a key role maintaining a low mutation load. Whereas it is generally agreed that TLS across...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.