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Article

Feedback regulation of apical progenitor fate by immature neurons through Wnt7-Celsr3-Fzd3 signalling.

Nature communications - 4 Mar 2016

Wang Wei, Jossin Yves, Chai Guoliang, Lien Wen-Hui, Tissir Fadel, Goffinet Andre M

Abstract excerpt

Sequential generation of neurons and glial cells during development is critical for the wiring and function of the cerebral cortex. This process requires accurate coordination of neural progenitor cell (NPC) fate decisions, by NPC-autonomous mechanisms as well as by negative feedback from neurons. Here, we show that neurogenesis is protracted and gliogenesis decreased in mice with mutations of genes Celsr3 and...

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Identifiers

PMID: 26939553
DOI: 10.1038/ncomms10936
PMCID: PMC4786577

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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