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Article

Apc1 is required for maintenance of local brain organizers and dorsal midbrain survival.

Developmental biology - 15 Jul 2009

Paridaen Judith T M L, Danesin Catherine, Elas Abu Tufayal, van de Water Sandra, Houart Corinne, Zivkovic Danica

Abstract excerpt

The tumor suppressor Apc1 is an intracellular antagonist of the Wnt/beta-catenin pathway, which is vital for induction and patterning of the early vertebrate brain. However, its role in later brain development is less clear. Here, we examined the mechanisms underlying effects of an Apc1 zygotic-effect mutation on late brain development in zebrafish. Apc1 is required for maintenance of established brain...

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PMID: 19397905
DOI: 10.1016/j.ydbio.2009.04.022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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