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Article

Targeted deletion of the C-terminus of the mouse adenomatous polyposis coli tumor suppressor results in neurologic phenotypes related to schizophrenia.

Molecular brain - 29 Mar 2014

Onouchi Takanori, Kobayashi Katsunori, Sakai Kazuyoshi, Shimomura Atsushi, Smits Ron, Sumi-Ichinose Chiho, Kurosumi Masafumi, Takao Keizo, Nomura Ryuji, Iizuka-Kogo Akiko, Suzuki Hidenori, Kondo Kazunao, Akiyama Tetsu, Miyakawa Tsuyoshi, Fodde Riccardo, Senda Takao

Abstract excerpt

BACKGROUND: Loss of adenomatous polyposis coli (APC) gene function results in constitutive activation of the canonical Wnt pathway and represents the main initiating and rate-limiting event in colorectal tumorigenesis. APC is likely to participate in a wide spectrum of biological functions via it...

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Identifiers

PMID: 24678719
DOI: 10.1186/1756-6606-7-21
PMCID: PMC3986642

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24678719-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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