Article
Targeted deletion of the C-terminus of the mouse adenomatous polyposis coli tumor suppressor results in neurologic phenotypes related to schizophrenia.
Molecular brain - 29 Mar 2014
Onouchi Takanori, Kobayashi Katsunori, Sakai Kazuyoshi, Shimomura Atsushi, Smits Ron, Sumi-Ichinose Chiho, Kurosumi Masafumi, Takao Keizo, Nomura Ryuji, Iizuka-Kogo Akiko, Suzuki Hidenori, Kondo Kazunao, Akiyama Tetsu, Miyakawa Tsuyoshi, Fodde Riccardo, Senda Takao
Abstract excerpt
BACKGROUND: Loss of adenomatous polyposis coli (APC) gene function results in constitutive activation of the canonical Wnt pathway and represents the main initiating and rate-limiting event in colorectal tumorigenesis. APC is likely to participate in a wide spectrum of biological functions via its different functional domains and is abundantly expressed in the brain as well as in peripheral tissues. However, the...
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