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Article

Arrhythmia phenotype in mouse models of human long QT.

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing - 1 Mar 2009

Salama Guy, Baker Linda, Wolk Robert, Barhanin Jacques, London Barry

Abstract excerpt

Enhanced dispersion of repolarization (DR) was proposed as a unifying mechanism, central to arrhythmia genesis in the long QT (LQT) syndrome. In mammalian hearts, K(+) channels are heterogeneously expressed across the ventricles resulting in 'intrinsic' DR that may worsen in long QT. DR was shown to be central to the arrhythmia phenotype of transgenic mice with LQT caused by loss of function of the dominant mouse...

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Source

Identifiers

PMID: 19148726
DOI: 10.1007/s10840-008-9339-6

Genes

KCNH2
ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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