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Replacement by Homologous Recombination of the <i>minK</i> Gene With <i>lacZ</i> Reveals Restriction of <i>minK</i> Expression to the Mouse Cardiac Conduction System

5 Feb 1999

Abstract excerpt

The minK gene encodes a 129-amino acid peptide the expression of which modulates function of cardiac delayed rectifier currents (IKr and IKs), and mutations in minK are now recognized as one cause of the congenital long-QT syndrome. We have generated minK-deficient mice in which the bacterial lacZ gene has been substituted for the minK coding region such that beta-galactosidase expression is controlled by...

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Share to Cardiac electrophysiology and arrhythmias
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PMID: 9933245
DOI: 10.1161/01.res.84.2.146

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Replacement by Homologous Recombination of the <i>minK</i> Gene With <i>lacZ</i> Reveals Restriction of <i>minK</i> Expression to the Mouse Cardiac Conduction SystemPMID 9933245Read ↗

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