Article
The multifaceted phenotype of the knockout mouse for the KCNE1 potassium channel gene.
American journal of physiology. Regulatory, integrative and comparative physiology - 1 Mar 2002
Warth Richard, Barhanin Jacques
Abstract excerpt
Mutations of the KCNE1 gene (IsK, minK) are related to hereditary forms of cardiac arrhythmias, so-called long QT syndromes (LQT). Here we review the phenotype of a mouse model for the recessive form of LQT known as Jervell and Lange-Nielsen syndrome. KCNE1 knockout mice exhibit an enhanced QT-RR adaptability, which is probably part of the pathophysiological mechanism leading to life-threatening tachyarrhythmia...
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