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Article

In vivo effect of a dominant negative Kv4.2 loss-of-function mutation eliminating I(to,f) on atrial refractoriness and atrial fibrillation in mice.

Circulation journal : official journal of the Japanese Circulation Society - 1 Mar 2009

Odening Katja E, Nerbonne Jeanne M, Bode Christoph, Zehender Manfred, Brunner Michael

Abstract excerpt

BACKGROUND: Gain-of-function K(+) channel mutations cause familial atrial fibrillation (AF) by shortening of the atrial action potential duration (APD). APD-prolonging K(+) channel blockers are an effective therapeutic option in AF. In vitro, the dominant negative Kv4.2W362F mutation (Kv4DN) elim...

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Source

Identifiers

PMID: 19145035
DOI: 10.1253/circj.cj-08-0840

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19145035-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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