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Article

Dispersion of repolarization and refractoriness are determinants of arrhythmia phenotype in transgenic mice with long QT.

The Journal of physiology - 1 Jan 2007

London Barry, Baker Linda C, Petkova-Kirova Polina, Nerbonne Jeanne M, Choi Bum-Rak, Salama Guy

Abstract excerpt

Enhanced dispersion of repolarization (DR) and refractoriness may be a unifying mechanism central to arrhythmia genesis in the long QT (LQT) syndrome. The role of DR in promoting arrhythmias was investigated in several strains of molecularly engineered mice: (a) Kv4.2 dominant negative transgenic (Kv4.2DN) that lacks the fast component of the transient outward current, I(to,f), have action potential (AP) and QT...

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Identifiers

PMID: 17110412
DOI: 10.1113/jphysiol.2006.122622
PMCID: PMC2075135

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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