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Article

Inducible polymorphic ventricular tachyarrhythmias in a transgenic mouse model with a long Q-T phenotype.

American journal of physiology. Heart and circulatory physiology - 1 Jun 2000

Jeron A, Mitchell G F, Zhou J, Murata M, London B, Buckett P, Wiviott S D, Koren G

Abstract excerpt

We created a mouse model with a prolonged Q-T interval and spontaneous arrhythmias by overexpressing the NH(2) terminus and first transmembrane segment (Kv1.1N206Tag) of a delayed rectifier potassium channel (LQT(+/-) mouse). Analyses were performed using whole cell recordings of cardiac myocytes, surface electrocardiography, and programmed electrical stimulation. Action potential duration (APD) was prolonged to...

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Source

Identifiers

PMID: 10843886
DOI: 10.1152/ajpheart.2000.278.6.H1891

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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