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Article

Overlap syndrome of cardiac sodium channel disease in mice carrying the equivalent mutation of human SCN5A-1795insD.

Circulation - 12 Dec 2006

Remme Carol Ann, Verkerk Arie O, Nuyens Dieter, van Ginneken Antoni C G, van Brunschot Sandra, Belterman Charly N W, Wilders Ronald, van Roon Marian A, Tan Hanno L, Wilde Arthur A M, Carmeliet Peter, de Bakker Jacques M T, Veldkamp Marieke W, Bezzina Connie R

Abstract excerpt

BACKGROUND: Patients carrying the cardiac sodium channel (SCN5A) mutation 1795insD show sudden nocturnal death and signs of multiple arrhythmia syndromes including bradycardia, conduction delay, QT prolongation, and right precordial ST-elevation. We investigated the electrophysiological characteristics of a transgenic model of the murine equivalent mutation 1798insD. METHODS AND RESULTS: On 24-hour continuous...

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PMID: 17145985
DOI: 10.1161/CIRCULATIONAHA.106.653949

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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