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Article

Genetic Loss of IK1 Causes Adrenergic-Induced Phase 3 Early Afterdepolariz ations and Polymorphic and Bidirectional Ventricular Tachycardia.

Circulation. Arrhythmia and electrophysiology - 1 Sept 2020

Reilly Louise, Alvarado Francisco J, Lang Di, Abozeid Sara, Van Ert Hannah, Spellman Cordell, Warden Jarrett, Makielski Jonathan C, Glukhov Alexey V, Eckhardt Lee L

Abstract excerpt

BACKGROUND: Arrhythmia syndromes associated with KCNJ2 mutations have been described clinically; however, little is known of the underlying arrhythmia mechanism. We create the first patient inspired KCNJ2 transgenic mouse and study effects of this mutation on cardiac function, IK1, and Ca2+ handling, to determine the underlying cellular arrhythmic pathogenesis. METHODS: A cardiac-specific KCNJ2-R67Q mouse was...

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Identifiers

PMID: 32931337
DOI: 10.1161/CIRCEP.120.008638
PMCID: PMC7574954

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