Age-dependent electrical and morphological remodeling of the Drosophila heart caused by hERG/seizure mutations.

doi:10.1371/journal.pgen.1006786

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Article

Age-dependent electrical and morphological remodeling of the Drosophila heart caused by hERG/seizure mutations.

PLoS genetics - 1 May 2017

Ocorr Karen, Zambon Alexander, Nudell Yoav, Pineda Santiago, Diop Soda, Tang Min, Akasaka Takeshi, Taylor Erika

Abstract excerpt

Understanding the cellular-molecular substrates of heart disease is key to the development of cardiac specific therapies and to the prevention of off-target effects by non-cardiac targeted drugs. One of the primary targets for therapeutic intervention has been the human ether a go-go (hERG) K+ channel that, together with the KCNQ channel, controls the rate and efficiency of repolarization in human myocardial...

Topics

Action Potentials
Animals
Arrhythmias, Cardiac
Drosophila
Drosophila Proteins
KCNQ Potassium Channels
Mutation
Myocytes, Cardiac

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Identifiers

PMID: 28542428
DOI: 10.1371/journal.pgen.1006786
PMCID: PMC5459509

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