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Article

Age-dependent electrical and morphological remodeling of the Drosophila heart caused by hERG/seizure mutations.

PLoS genetics - 1 May 2017

Ocorr Karen, Zambon Alexander, Nudell Yoav, Pineda Santiago, Diop Soda, Tang Min, Akasaka Takeshi, Taylor Erika

Abstract excerpt

Understanding the cellular-molecular substrates of heart disease is key to the development of cardiac specific therapies and to the prevention of off-target effects by non-cardiac targeted drugs. One of the primary targets for therapeutic intervention has been the human ether a go-go (hERG) K+ channel that, together with the KCNQ channel, controls the rate and efficiency of repolarization in human myocardial...

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Identifiers

PMID: 28542428
DOI: 10.1371/journal.pgen.1006786
PMCID: PMC5459509

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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