Dicer Is Required for Maintaining Adult Pancreas

Abstract excerpt

Dicer1, an essential component of RNA interference and the microRNA pathway, has many important roles in the morphogenesis of developing tissues. Dicer1 null mice have been reported to die at E7.5; therefore it is impossible to study its function in adult tissues. We previously reported that Dicer1-hypomorphic mice, whose Dicer1 expression was reduced to 20% in all tissues, were unexpectedly viable. Here we...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to MicroRNA in disease regulation
• Share to Pancreatic function and diabetes
• Share to RNA modifications and cancer