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Article

Dicer1 Is Required for Differentiation of the Mouse Male Germline1

17 Jul 2008

Abstract excerpt

MicroRNAs (miRNAs) are small noncoding RNAs that posttranscriptionally regulate gene expression. Hundreds of miRNAs are expressed in mammals; however, their functions are just starting to be uncovered. MicroRNAs are processed from a long hairpin mRNA transcript, down to a approximately 23-nucleotide duplex. The enzyme Dicer1 is required for miRNA processing, and mouse knockouts of Dicer1 are embryonic lethal...

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PMID: 18633141
DOI: 10.1095/biolreprod.108.067827

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