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MicroRNA Expression Is Required for Pancreatic Islet Cell Genesis in the Mouse

6 Sept 2007

Abstract excerpt

OBJECTIVE: The generation of distinct cell types during the development of the pancreas depends on sequential changes in gene expression. We tested the hypothesis that microRNAs (miRNAs), which limit gene expression through posttranscriptional silencing, modulate the gene expression cascades involved in pancreas development. RESEARCH DESIGN AND METHODS: miRNAs were cloned and sequenced from developing pancreata,...

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PMID: 17804764
DOI: 10.2337/db07-0175

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