Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dysregulation of Dicer1 in beta cells impairs islet architecture and glucose metabolism.

Experimental diabetes research - 1 Jan 2012

Mandelbaum Amitai D, Melkman-Zehavi Tal, Oren Roni, Kredo-Russo Sharon, Nir Tomer, Dor Yuval, Hornstein Eran

Abstract excerpt

microRNAs (miRNAs) play important roles in pancreas development and in regulation of insulin expression in the adult. Here we show that loss of miRNAs activity in beta-cells during embryonic development results in lower beta-cell mass and in impaired glucose tolerance. Dicer1-null cells initially constitute a significant portion of the total beta-cell population. However, during postnatal development, Dicer1-null...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DEAD-box RNA Helicases
Share to Glucose Intolerance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin-Secreting Cells

Share to Insulin Secretion

Share to Integrases

Share to Islets of Langerhans

Share to Organogenesis

Share to Ribonuclease III

Source

Open in PubMed Open full text

Identifiers

PMID: 22991506
DOI: 10.1155/2012/470302
PMCID: PMC3443614

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dysregulation of Dicer1 in beta cells impairs islet architecture and glucose metabolism.PMID 22991506Read ↗

Beta-Cell Specific Deletion of Dicer1 Leads to Defective Insulin Secretion and Diabetes MellitusSemantic proximity Read ↗

MicroRNA Expression Is Required for Pancreatic Islet Cell Genesis in the MouseSemantic proximity Read ↗

Dicer Is Required for Maintaining Adult PancreasSemantic proximity Read ↗

DICER Inactivation Identifies Pancreatic β-Cell “Disallowed” Genes Targeted by MicroRNAsSemantic proximity Read ↗

On the Chopping Block: Overview of DICER1 Mutations in Endocrine and Neuroendocrine Neoplasms.Semantic proximity Read ↗

On the Chopping Block: Overview of DICER1 Mutations in Endocrine and Neuroendocrine Neoplasms.Semantic proximity Read ↗

Pdx1 regulates pancreas tubulogenesis and E-cadherin expressionSemantic proximity Read ↗

Raptor regulates functional maturation of murine beta cellsSemantic proximity Read ↗

Nkx6.1 Is Essential for Maintaining the Functional State of Pancreatic Beta CellsSemantic proximity Read ↗

Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expressionSemantic proximity Read ↗

MiRNAs in β-Cell Development, Identity, and DiseaseSemantic proximity Read ↗

Loss of Dicer1 impairs hepatocyte survival and leads to chronic inflammation and progenitor cell activation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.